The Japanese diet may slow the progression of fatty liver disease – Medical News Today

NAFLD is a largely symptomless condition in which fat builds up in the liver, potentially affecting the function of the organ, although it does not directly damage it.

With NAFLD, a person is at higher risk of non-liver malignancies such as colorectal cancer, chronic kidney disease, gastroesophageal reflux, obstructive sleep apnea, hypothyroidism, periodontitis, polycystic ovarian syndrome, and psychological and growth hormone problems.

Dr. Muhammad Nadeem Aslam, assistant research scientist in the Department of Pathology of Michigan Medicine at the University of Michigan, who was not involved in the study, explained to Medical News Today the mechanics of how the disease develops:

“Utilization of excess fat, particularly saturated fat, along with processed carbohydrates — fructose, glucose, and sucrose — and too many calories lead to an imbalance between fat accumulation and breakdown in the liver, with fat buildup in the liver being the consequence.”

Michelle Routhenstein, heart health dietitian at EntirelyNourished.com, who was also not involved in the study, said:

“Foods that are rich in refined sugars, or saturated fat, salt, or trans fat can all promote fatty liver disease by increasing inflammation and insulin resistance and by adding more oxidative stress on the body.”

“While fatty infiltration is generally well-tolerated, the excess accumulation of lipids — including triglycerides, free fatty acids, and cholesterol — in the liver can result in cellular stress with the generation of reactive oxygen species,” Dr. Aslam elaborated.

Examples of NAFLD-promoting foods include hydrogenated oils, fried foods, juices, soda, and processed foods, noted Routhenstein.

The three most influential foods cited in the study have their own benefits, and share at least one attribute: They are low-fat.

“Soybeans, for instance, are rich in fiber plant proteins that are low in saturated fat,” said Dr. Aslam.

Routhenstein added that soy is “associated with higher muscle mass, given it is a complete protein which contains all essential amino acids to support muscle protein creation.”

“Seafood (mainly fish) is rich in omega-3 fatty acids and vitamins such as D and B2 (riboflavin). Fish is also rich in calcium and phosphorus and is a great source of minerals, such as iron, zinc, iodine, magnesium, and potassium,” said Dr. Aslam.

Routhenstein cited the anti-inflammatory and antioxidant properties of seafood for its potentially suppressive effect on fibrosis progression.

“Japanese seaweed is rich in polyphenols, vitamins, and minerals. Most edible algae contain a unique set of nutrients,” added Dr. Aslam, as well as vitamins.

Another diet known to be beneficial for people with NAFLD is the Mediterranean diet. It emphasizes plant-based elements, fruits, vegetables, nuts, legumes, whole grains, and lean meats.

Routhenstein cites one food in the mJDI12 index — green tea — as being especially helpful for NAFLD due to its antioxidant content.

It “has been shown to be protective against fatty liver disease because it contains about 200-300 mg of Epigallocatechin-3-gallate (EGCG) in one cup,” said Routhenstein.

Dr. Aslam mentioned antioxidant-rich coffee beans as also being associated with an overall lower risk for NAFLD.

“Raspberries are rich in insoluble fiber that helps create a short chain fatty acid in the gut called butyrate which studies have shown to be helpful in the reversal and prevention of fatty liver disease,” added Routhenstein said.

“This study emphasizes the opportunity to be proactive in your health by adding in therapeutic foods to help prevent the progression of fatty liver disease,” Routhenstein said.

Dr. Aslam expressed concern that so many Americans’ diet remains “far below dietary guidelines recommendations for healthy dietary patterns.”

“The lack of these nutrient-dense foods in the daily diets can cause diet-related chronic diseases, such as cardiovascular disease, type 2 diabetes, obesity, and fatty liver disease,” said Dr. Aslam.

Dr. Aslam extolled nutrient-rich diets, which have less in the way of sugars, saturated fat, and sodium:

“Vegetables, fruits, whole grains, seafood, eggs, beans, peas, and lentils, unsalted nuts and seeds, fat-free and low-fat dairy products, and lean meats and poultry — when prepared with no or little added sugars, saturated fat, and sodium — are nutrient-dense foods,” said Dr. Aslam.